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    Approved for treating diabetes, exenatide also induces weight loss in overweight diabetics. 46 This drug has been used off-label for weight loss, but apparently infrequently. Zonisamide. Approved for epilepsy, this drug induces weight loss and has been used off-label alone 47 or in combination with bupropion 48 or phentermine. Bupropion

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    The table below lists prescription drugs approved by the FDA for weight loss. The FDA has approved five of these drugsorlistat Xenical, Alli, phentermine-topiramate Qsymia, naltrexone-bupropion Contrave, liraglutide Saxenda, and semaglutide Wegovyfor long-term use.

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